The central giant cells granuloma of the mandible: a report of two cases and a review of the literature

Abstract

The central giant cells granuloma (CGCG) is a benign intraosseous lesion of the jaws. CGCG is found predominantly in children
and young adults, most commonly in the anterior portion of the mandible. Although many theories have been proposed to explain the
aetiology and pathogenesis of CGCG, its true nature is still unknown. In this study, two cases of CGCG are presented.
The first case is about a 7-year-old patient with a lesion of the mandible and the ectopic displacement of teeth n° 3.2 and n° 7.4.
The second case is about a 68-year-old man with a recidivant lesion of the mandible, that produced an external root resorption of
3.3, in the same site of a previously excised CGCG. In both cases a surgical excision of the lesion was performed and a histological
diagnosis of CGCG was made. The clinical and radiographic 4-years follow-up in the first case and a 2-years follow-up in the second
case did not reveal any recurrence of the lesion. So we may conclude that early and precise diagnosis of CGCG allows conservative
management without risks for the adjacent teeth or bone.