Infection and Colonization pattern in children with chronic granulomatous disease: a prospective cohort study

Heba Aly Abdelaty; Ghada Farouk Eldriny; Ashraf Ahmed Galal; Shams Abd El-Fattah Arafa; Walaa Shoman

Heba Aly Abdelaty Assistant Lecturer in Pediatrics, Faculty of Medicine, University of Alexandria
Ghada Farouk Eldriny
Ashraf Ahmed Galal
Shams Abd El-Fattah Arafa
Walaa Shoman

Keywords: Chronic granulomatous disease, NADPH oxidase, bacterial infections, normal flora, colonization, risk factors

Abstract

Backgrounds: Chronic granulomatous disease (CGD) is one of the most common primary immunodeficiency (PID) diseases characterized by an increased tendency to infection with catalase-positive organisms due to defective phagocytic killing mechanism. This study aimed to identify the microbiological colonization pattern in children with CGD and study the different characteristics encountered in different genetic subtypes. A prospective study was conducted on 18 CGD patients at Alexandria University Children's Hospital.

Methods: Samples for cultures from the oropharynx, skin and nasal cavity were obtained when the patients were in an infection-free period. The children's characteristics and different manifestations were studied in relation to the CGD subtypes.

Results: We found more normal flora colonizing p47 deficient patients (p= 0.015) while more pathogenic bacteria and Asperigellus fungal spp were detected in p91, X-linked CGD patients (p= 0.021, p=0.004 respectively).

Conclusions: Different frequencies of normal flora and pathogenic species could be isolated in colonization cultures of different CGD subtypes which may affect the infection pattern in each specific group.