Evaluating homocysteine as a biomarker for bipolar disorder

Abstract

Background: Bipolar disorder (BD) is a serious mental health disease that affects both men and women. The main objectives for this study were evaluating the level of homocysteine in bipolar patients, and clarification the association between Hyperhomocystinemia (HHcy) and clinical variables and disease severity among psychiatric inpatients in El-Hadara Alexandria university hospital psychiatric wards.

Method: 60 subjects (30 healthy control, 30 bipolar cases) Homocysteine levels was measured by chemiluminescence technique, then the cases group had been assessed by obtaining detailed clinical data concerning any change in disease severity and its correlation with homocysteine level

Results: homocysteine level was significantly higher in cases group (25.25 ± 12.93)than control group (9.88 ± 3.89),homocystiene level was positively correlated with severity of bipolar represented with clinical global impression scale.