Effectiveness of auto‐crosslinked hyaluronic acid gel in the prevention of intrauterine adhesions after hysteroscopic surgery

Abstract

Background: Intrauterine adhesions are a relevant short- or long-term result of hysteroscopic surgery, and the rate by which they develop depends mainly on the type of surgical procedure, being particularly high in the case of metroplasty, myomectomy, and endometrial ablations. The authors in this study sought to evaluate the effect of cross-linked hyaluronic acid in the prevention of intrauterine adhesions after different hysteroscopic procedures

Methods: The study was conducted on 60 females, the patients underwent different hysteroscopic surgeries (myomectomy and septum resection) then they were randomized to either group A or group B. Group A received 5 ml new crosslinked hyaluronic acid (NCH) intrauterine gel (MateRegen gel, Bioregen Biomedical Co.) at the end of the hysteroscopic procedure. Group B did not receive the gel after the hysteroscopic procedure. A second look hysteroscopy was done to all patients to evaluate the intrauterine adhesions.

Results: Our results showed that on second look hysteroscopy , adhesions was found in 3 patients (10%) in group A and in 9 patients (30.0%) in group B , there was a difference between both group but it was not statistically significant , p value = 0.053.

Conclusion: It seems hyaluronic acid gel can help reduce the incidence of intrauterine adhesions after hysteroscopy but the results were not statistically significant, further studies are needed with higher number of cases.