Pain in Ehlers-Danlos syndrome: a diagnostic and therapeutic challenge

Abstract

EDS patients shows chronic and frequently debilitating pain described from different authors as multifactorial. Pain has been
described as neuropathic in some individuals but probably the persistent nociceptive input due to joint abnormalities probably
triggers central sensitization in the dorsal horn neurons and causes widespread pain. The knowledge of the correct type of pain is
necessary for the correct management in particular for the rehabilitative approach.